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Journal: Cell Death Discovery
Article Title: GPR110 promotes progression and metastasis of triple-negative breast cancer
doi: 10.1038/s41420-022-01053-x
Figure Lengend Snippet: A Graph showing GPR110 expression in stage1 ( n = 371), stage2 ( n = 571), and stage3 ( n = 90) of breast cancers using the database from METABRIC breast cancer databases. B Tissue microarray analysis of GPR110 expression in different stages of breast cancer (left) and the proportion is shown in the graph (right). C Graph showing GPR110 expression in grade1 ( n = 170), grade2 ( n = 770), and grade3 ( n = 952) of breast cancers using the database from METABRIC breast cancer databases. D Tissue microarray analysis of GPR110 expression in different grades of breast cancer (left) and the proportion in shown in the graph (right). E Kaplan–Meier survival analysis showed that high expression of GPR110 was associated with a poor survival rate of breast cancer patients obtained from the GEO database (GSE25085, GSE11121). F Kapan–Meier survival analysis of metastatic breast cancer patients (GSE45255, GSE7390). G GSEA of metastasis and cancer progression signature to GPR110 expression in breast cancer patients. H Schematic of GPR110/Gαs/RAS signaling axis mechanism in breast cancer. * p < 0.05, ** p < 0.001 and **** p < 0.0001; ns not significant; determined by two-tailed Student’s t test (95% confidence interval).
Article Snippet:
Techniques: Expressing, Microarray, Two Tailed Test